O-GlcNAcase Inhibitor ASN90 is a Multimodal Drug Candidate for Tau and α-Synuclein Proteinopathies

Permanne B, Sand A, Ousson S, Nény M, Hantson J, Schubert R, Wiessner C, Quattropani A, Beher*

ACS Chem. Neurosci. 2022, 13, 8, 1296–1314
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Current directions in tau research: Highlights from Tau 2020

Sexton C, Snyder H, Beher D, Boxer A, Brannelly P, Brion JP, Buée L, Cacace A, Chételat G, Citron M, DeVos S, Diaz K, Feldman H, Frost B, Goate A, Gold M, Hyman B, Johnson K, Karch C, Kerwin D, Koroshetz W, Litvan I, Morris H, Mummery C, Mutamba J, Patterson M, Quiroz Y, Rabinovici G, Rommel A, Shulman M, Toledo-Sherman L, Weninger S, Wildsmith K, Worley S, Carrillo M.

Alzheimer’s Dement. 2021;1-20.
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Alzheimer's disease mutations in APP but not gamma-secretase modulators affect epsilon-cleavage-dependent AICD production.

Dimitrov M, Alattia, JR, Lemmin T, Rajwinder L, Fligier A, Houacine J, Hussain I, Radtke F, Dal Peraro M, Beher D, and Fraering PC.
Nat. Commun. 4 (2013), 2246 ff
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Generation and characterization of a rabbit monoclonal antibody site-specific for tau O-GlcNAcylated at serine 400.

Cameron A, Giacomozzi B, Joyce J, Gray A, Graham D, Ousson S, Neny M, Beher D, Carlson G, O'Moore J, Shearman M, Hering H.
FEBS Lett. 2013 Nov; 586 (22): 3722 - 28
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Substrate determinants in the C99 juxtamembrane domains differentially affect γ-secretase cleavage specificity and modulator pharmacology.

Ousson S, Saric A, Baguet A, Losberger C, Genoud S, Vilbois F, Permanne B, Hussain I, Beher D.
J Neurochem. 125 (2013), 610-619 
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The role of γ-Secretase Activating Protein, GSAP and imatinib in the regulation of γ-secretase activity and amyloid-β generation.

Hussain I, Fabregue J, Anderes L, Ousson S, Borlat F, Eligert V, Berger S, Dimitrov M, Alattia JR, Fraering PC, Beher D.
J Biol Chem. 2013 Jan ; 288 (4): 2521-31
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Development and Characterization of a Novel Membrane Assay for Full-Length BACE-1 at pH 6.0.

Saric A, Brügge LZ, Müller-Pompalla D, Rysiok T, Ousson S, Permanne B, Quattropani A, Busch M, Beher D, Hussain I.
J Biomol Screen. 2012 Sep 27. [Epub ahead of print]
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Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.

Zettl H, Ness J, Hähnke V, Beher D, Jumpertz T, Saric A, Baumann K, Pietrzik CU, Bulic B, Schneider G, Weggen S.
ACS Chem Biol. 2012 Sep 21;7(9): 1488-95.
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Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's disease.

Weggen S, Beher D.
Alzheimers Res Ther. 2012 Mar 30;4(2):9
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